• General

    P53 research

    What is the role of the p53 gene? It does this remains unclear, although the p53 gene is vital for tumor suppression. Upon genotoxic or oncogenic tests, increased p53 activity causes uncontrollable cell cycle arrest, senescence or apoptosis. The 3 cornerstones of those so-called triumvirate. Therefore, it’s long been believed that p53 inhibits tumorigenesis by counteracting cell survival or proliferation. Several clarified mice imply without activating these three answers that p53 can suppress tumorigenesis. As a significant mechanism for tumor reduction, these mice stage to p53to’s capability stop the Warburg effect, which would be to soften glycolysis and boost respiration. Collectively, these”conservative” actions of p53 may protect against tumor initiation…