SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

Human hexokinase 2 is a vital regulator of glycolysis that {couples} metabolic and proliferative actions in cancer cells. The binding of hexokinase 2 to the outer membrane of mitochondria is vital for its oncogenic exercise. However, the regulation of hexokinase 2 binding to mitochondria stays unclear. Here, we report that SUMOylation regulates the binding of hexokinase 2 to mitochondria. We discover that hexokinase 2 will be SUMOylated at Ok315 and Ok492. SUMO-specific protease SENP1 mediates the de-SUMOylation of hexokinase 2. SUMO-defective hexokinase 2 ideally binds to mitochondria and enhances each glucose consumption and lactate manufacturing and decreases mitochondrial respiration in parallel.

This metabolic reprogramming helps prostate cancer cell proliferation and protects cells from chemotherapy-induced cell apoptosis. Moreover, we display an inverse relationship between SENP1-hexokinase 2 axis and chemotherapy response in prostate cancer samples. Our knowledge present proof for a beforehand uncovered posttranslational modification of hexokinase 2 in cancer cells, suggesting a probably actionable technique for stopping chemotherapy resistance in prostate cancer. Glomerulonephritis is the one of the main causes of the end-stage kidney illness, whereas the pathological course of of glomerulonephritis remains to be not fully understood. Single-cell RNA sequencing (scRNA-seq) emerges to be a strong instrument to consider the full heterogeneity of kidney ailments.

To reveal mobile gene expression profiles of glomerulonephritis, we carried out scRNA-seq of 2 human kidney transplantation donor samples, four human glomerulonephritis samples, 1 human malignant hypertension (MH) pattern and 1 human persistent interstitial nephritis (CIN) pattern, all tissues have been taken from the biopsy. After filtering the cells with < 200 genes and > 10% mitochondria (MT) genes, the ensuing 14 932 cells will be divided into 20 cell clusters, persistently with the earlier report, in illness samples dramatic immune cells infiltration was discovered, amongst which a proximal tubule (PT) subset characterised by wnt-β catenin activation and a pure killer T (NKT) subset excessive expressing LTB have been discovered. Furthermore, in the cluster of the podocyte, three glomerulonephritis associated genes named FXYD5, CD74 and B2M have been discovered.

Mechanisms underlying the hormetic impact of conjugated linoleic acid: deal with Nrf2, mitochondria and NADPH oxidases

Nuclear issue erythroid 2-related factor2 (Nrf2) is a redox-sensitive transcription issue. Its activation by low dietary consumption of ligands leads to antioxidant results (eustress), whereas pro-oxidant results (oxidative misery) could also be related to excessive doses. NADPH oxidases (NOXs) and the mitochondrial electron transport chain are the most important sources of intracellular ROS, however their involvement in the biphasic/hormetic exercise elicited by Nrf2 ligands is just not absolutely understood. In this examine, we investigated the involvement of NOX expression and mitochondrial operate in the hormetic properties of omega-Three sometimes current in fish oil (FO) and conjugated linoleic acid (CLA) in the mouse liver.

Four-week administration of FO, at each low and excessive doses (L-FO and H-FO) improves Nrf2-activated cyto-protection (by section 2 enzymes), whereas a big improve in respiration effectivity happens in the liver mitochondria of H-FO BALB/c mice. Eustress circumstances elicited by low dose CLA (L-CLA) are related to elevated exercise of section 2 enzymes, and with greater NOX1-2, mitochondrial defences, mitochondrial uncoupling protein 2 (UCP2), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) expression, in contrast with controls.

Steatogenic results (lipid accumulation and alteration of lipid metabolism) elicited by excessive CLA (H-CLA) elicited which can be related to oxidative misery, elevated mitochondrial advanced I/III exercise and lowered ranges of section 2 enzymes, compared with L-CLA-treated mice. Our outcomes verify the steatogenic exercise of H-CLA and first display the function of NOX1 and NOX2 in the eustress circumstances elicited by L-CLA. Notably, the unfavourable affiliation of the Nrf2/PGC-1α axis with the totally different CLA doses supplies new perception into the mechanisms underlying the hormetic impact triggered by this Nrf2 ligand. This overview focusses on latest, structural findings on the regulation of Parkin exercise. What follows is a mechanistic introduction to the household of E3 ligases that features

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

A mechanistic overview of Parkin activation

Parkin and phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) represent a feed-forward signalling pathway that mediates autophagic elimination of broken mitochondria (mitophagy). With over 130 mutations recognized to date in over 1000 sufferers with early onset parkinsonism, Parkin is taken into account a sizzling spot of signalling pathways concerned in PD aetiology. Parkin is an E3 ligase and how its exercise is regulated has been extensively studied: inter-domain interactions exert a decent inhibition on Parkin exercise; binding to phospho-ubiquitin relieves this auto-inhibition; and phosphorylation of Parkin shifts the equilibrium in the direction of maximal Parkin activation.

Human Anti-S. Pneumococcal polysaccharide serotype 5 antiserum

560-052-S 100 ul
EUR 445

Rabbit Anti-Sm28/Smp28/GST28/GST-mu protein (S. Japonicum, 1-211aa) antiserum

SM282-S 100 ul
EUR 457

Total Protein Extraction Kit for Muscles (50 tests)

P5A06 - Ask for price

Rabbit Anti-S. Pneumococcal Serotype 23F Carbohydrate (Spn23F) Antiserum

SPN231-S 100 ul
EUR 445

Human ATP synthase subunit s, mitochondrial, ATP5S ELISA KIT

ELI-11417h 96 Tests
EUR 824

Human Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E01C1746-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E01C1746-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E01C1746-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E01A1107-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E01A1107-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E01A1107-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Creatine kinase S- type, mitochondrial, CKMT2 ELISA KIT

ELI-38194h 96 Tests
EUR 824

ATP Synthase Subunit S, Mitochondrial (ATP5S) Antibody

abx036367-100ug 100 ug
EUR 391

ATP Synthase Subunit S, Mitochondrial (ATP5S) Antibody

20-abx008196
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

ATP Synthase Subunit S, Mitochondrial (ATP5S) Antibody

20-abx014225
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

ATP Synthase Subunit S, Mitochondrial (ATP5S) Antibody

abx031464-400ul 400 ul
EUR 523

ATP Synthase Subunit S, Mitochondrial (ATP5S) Antibody

abx031464-80l 80 µl
EUR 286

Rabbit Anti-Rat Dopamine Receptor 2 (D2R) (L/S) Antiserum # 1

D2R11-S 100 ul
EUR 457

Rabbit Anti-Glutathione Transferase, GST (S. japonicum, E. coli) antiserum # 1

GST11-S 100 ul
EUR 457

Human Protein S Antibody

11781-05011 150 ug
EUR 217

Human Protein S (PROS) Protein

abx670077-50ug 50 ug
EUR 300

Human Protein S (PROS) Protein

20-abx068765
  • EUR 495.00
  • EUR 244.00
  • EUR 1414.00
  • EUR 578.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Protein S (PROS) Protein

20-abx068766
  • EUR 495.00
  • EUR 244.00
  • EUR 1414.00
  • EUR 578.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Free Protein S,FP-S ELISA Kit

CN-04320H1 96T
EUR 449

Human Free Protein S,FP-S ELISA Kit

CN-04320H2 48T
EUR 299

Human Free Protein S,FP-S ELISA Kit

201-12-1176 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Free Protein S(FP-S)ELISA Kit

GA-E1192HM-48T 48T
EUR 289

Human Free Protein S(FP-S)ELISA Kit

GA-E1192HM-96T 96T
EUR 466

Human Free Protein S(FP-S)ELISA Kit

QY-E00408 96T
EUR 361

Rabbit Anti-S. Pneumococcal polysaccharide serotype 5 antiserum

560-051-S 100 ul
EUR 445

Rabbit Anti-Sm-p80/Calpain/CANP (S. mansoni, 1-758aa, His-tag >95%) antiserum

SMP801-S 100 ul
EUR 457

Human Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (RSAD1) ELISA Kit

abx385342-96tests 96 tests
EUR 911

Human Troponin C, slow skeletal and cardiac muscles, TNNC1 ELISA

ELI-40072h 96 Tests
EUR 824

Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (RSAD1) Antibody

abx330653-100ul 100 ul
EUR 425

Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (RSAD1) Antibody

20-abx326028
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Radical S-Adenosyl Methionine Domain-Containing Protein 1, Mitochondrial (RSAD1) Antibody

20-abx133527
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Radical S-Adenosyl Methionine Domain-Containing Protein 1, Mitochondrial (RSAD1) Antibody

20-abx014776
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Human Peptidoglycan Recognition Protein-S (PGRP-S) ELISA Kit

abx358442-96tests 96 tests
EUR 668

Human Peptidoglycan Recognition Protein-S (PGRP-S) CLIA Kit

abx197420-96tests 96 tests
EUR 825

Human Peptidoglycan Recognition Protein S (PGRP-S) ELISA Kit

abx252952-96tests 96 tests
EUR 637

Human PGRP-S(Peptidoglycan Recognition Protein-S) ELISA Kit

EH3565 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human Protein S ELISA Kit

ELA-E0735h 96 Tests
EUR 824

Human Protein S ELISA Kit

CN-04470H1 96T
EUR 442

Human Protein S ELISA Kit

CN-04470H2 48T
EUR 293

Human Protein S ELISA kit

E01P0144-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Protein S in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Protein S ELISA kit

E01P0144-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Protein S in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Protein S ELISA kit

E01P0144-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Protein S in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Protein S ELISA Kit

CSB-E09903h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Protein S in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Protein S ELISA Kit

1-CSB-E09903h
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Protein S in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Protein S ELISA Kit

201-12-1177 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neuropeptide S (NPS) Protein

20-abx652330
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Brain S-100 Protein

abx060914-1mg 1 mg
EUR 1497

Human Brain S-100B Protein

abx060915-1mg 1 mg
EUR 3502

Human S Antigen (SAG) Protein

20-abx068943
  • EUR 676.00
  • EUR 286.00
  • EUR 2082.00
  • EUR 801.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Cathepsin S (CTSS) Protein

20-abx065830
  • EUR 620.00
  • EUR 272.00
  • EUR 1887.00
  • EUR 746.00
  • EUR 453.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human S-100 Protein Antibody

11561-05011 150 ug
EUR 217

Human S-100BB Protein Antibody

12661-05011 150 ug
EUR 217

Human S-100BB Protein Antibody

42661-05011 150 ug
EUR 217

Recombinant Human Cystatin S Protein

RP00994 5 μg
EUR 136

Human Protein S ELISA Kit

EHP0730 96Tests
EUR 521

Mitochondrial Protein

abx061499-200ug 200 ug
EUR 648

Rabbit Creatine kinase S- type, mitochondrial, CKMT2 ELISA KIT

ELI-14130Ra 96 Tests
EUR 928

Bovine Creatine kinase S- type, mitochondrial, CKMT2 ELISA KIT

ELI-21292b 96 Tests
EUR 928

Mouse Creatine kinase S- type, mitochondrial, Ckmt2 ELISA KIT

ELI-31156m 96 Tests
EUR 865

Rat Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E02C1746-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E02C1746-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E02C1746-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E02A1107-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E02A1107-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E02A1107-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E03C1746-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E03C1746-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E03C1746-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E04C1746-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E04C1746-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E04C1746-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E04A1107-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E04A1107-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E04A1107-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E03A1107-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E03A1107-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E03A1107-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E06C1746-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E06C1746-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E06C1746-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E09C1746-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E09C1746-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Creatine kinase S type, mitochondrial(CKMT2) ELISA kit

E09C1746-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Creatine kinase S type, mitochondrial(CKMT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E09A1107-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E09A1107-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E09A1107-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Bovine ATP synthase subunit s, mitochondrial, ATP5S ELISA KIT

ELI-34791b 96 Tests
EUR 928

Chicken Creatine kinase S- type, mitochondrial, CKMT2 ELISA KIT

ELI-38193c 96 Tests
EUR 928

Mouse ATP synthase subunit s, mitochondrial, Atp5s ELISA KIT

ELI-49005m 96 Tests
EUR 865

Goat ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E06A1107-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat ATP synthase subunit s, mitochondrial(ATP5S) ELISA kit

E06A1107-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat ATP synthase subunit s, mitochondrial(ATP5S) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ADSL expression ranges have been assessed by immunohistochemistry or retrieved from The Cancer Genome Atlas (TCGA) dataset. The results of ADSL silencing or overexpression have been evaluated on CRC cell proliferation, cell migration and cell-cycle. In vivo tumor progress was assessed by the rooster chorioallantoic membrane (CAM). Transfected cell traces or patient-derived organoids (PDO) have been handled with 5-fluorouracil (5-FU) and 6-mercaptopurine (6-MP) and drug response was correlated with ADSL expression ranges. Metabolomic and transcriptomic profiling have been carried out to determine dysregulated pathways and ADSL downstream effectors.

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